Know this (τουτο γινωσκε). See 1. Corinthians 11:3; Philippians 1:12.

In the last days (εν εσχαταις ημεραις). See James 5:3; 1. Timothy 4:1.

Grievous (χαλεπο). Hard. See Ephesians 5:16.

Shall come (ενστησοντα). Future middle of ενιστημ (intransitive use), old verb, to stand on or be at hand, as in 2. Thessalonians 2:2.